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Antigenic Protein OfBorrelia Burgdorferi

This patent application describes a 39 kDa protein (P39) that is species-specific and expressed by all North American and EuropeanB. burgdorferiisolates. The discovery includes the cloning and expression of the gene for P39 inE. coliand the use of P39 as a diagnostic antigen for the serodiagnosis of Lyme borreliosis. The P39 described in this invention report has been found not only to be species-specific, but reactive only with human Lyme borreliosis sera. This suggests that any patient's serum that is shown to react to P39, irrespective of the patient's clinical picture, can be diagnosed as having or having had Lyme borreliosis. Warren Simpson (NIAID)➽ more inventions...
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