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Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration

These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.
Patent Abstract: 
These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo. Katherine Malinda (NIDCR)➽ more inventions... Hynda Kleinman (NIDCR)➽ more inventions... Allan Goldstein US Application No. 60/065,032 This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998). Yun Mei, Email:yun.mei@nih.gov Phone: 301-594-3617 E-250-1997/0 Updated:May 16, 2016
Inventors: 
Katherine Malinda
Internal Laboratory Ref #: 
E-250-1997/0
Lab Representatives
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