Name of License: HART mice
Summary: Androgen receptor (AR) plays a critical role in prostate cancer. Length of AR’s N-terminal glutamine (Q) tract has been associated with disease risk, and AR somatic mutation may influence disease progression. To study the basis for these effects in an animal model, the mouse AR gene was converted to the human sequence, using homologous recombination in embryonic stem cells.
Dates: Period of time for comments 06/22/2021 - 07/07/2021.
Address: 1590 Freedman Drive
Fort Detrick, MD 21702