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Displaying 81 - 90 of 17291
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Stat1LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies
Selective inactivation of Stat1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.
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Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse Model for Developmental Biology Studies
Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-apoptotic Bax during embryogenesis.
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N-Methanocarba Adenosine Derivatives and Their Dendrimer Conjugates as A3 Receptor Agonists
This technology relates to specific (N)-methanocarba adenine nucleosides that have been developed and dendrimers that connect these compounds to create molecules with multiple targets. Dendrimers are essentially repeated molecular branches presenting the core receptor-binding molecules. The...
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Rabbit Antibody to Mouse Sphingosine-1-phosphate (S1P) lyase
The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. Researchers at NIH injected rabbits with the C-terminal peptide of the mouse S1P lyase — 551-...
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Fgfr3 Knockout Mouse Model for Developmental Biology Studies
FGFR3 knockout. Complete knockout of the FGFR3 gene, the gene in which missense mutants cause short statue achondroplasia, fails to restrain cartilage growth at the bone growth plate, allowing bones to elongate excessively but fail to ossify.
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Methanocarba Cycloalkyl Nucleoside Analogues
Purines such as adenosine and ATP have been shown to play a wide array of roles in biological systems such as inter alia, modulator of vasodilation and hypotension, muscle relaxant, central depressant, inhibitor of platelet aggregation, regulator of energy supply/demand, responder to oxygen...
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Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental Biology Studies
FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation.
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Fgfr4 Knockout Mouse Model for Respiratory System Studies
FGFR4 knockout: Lung alveoli fail to develop normally in double mutant with FGFR4 and FGFR3 knockouts.
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Generation of Smad3-null Mice and Smad4-conditional Mice
SMADs are a novel set of mammalian proteins that act downstream of TGF-beta family ligands. These proteins can be categorized into three distinct functional sets, receptor-activated SMADs (SMADs 1,2,3,5, and 8), the common mediator SMAD (SMAD 4), and inhibitory SMADs (SMADs 6 and 7). SMAD proteins...