Center for Structural Molecular Biology (CSMB)

Agency/Department

FLC Region

Security Lab

No

Address

1 Bethel Valley Rd
Oak Ridge, TN 37830
United States

(P)

865-576-0666

Description

[Part of the High Flux Isotope Reactor user facility.] ORNL's CSMB is dedicated to developing instrumentation and methods for determining the 3-dimensional structures of proteins, nucleic acids (DNA/RNA) and their higher order complexes. The tools of the CSMB help understand how these macromolecular systems are formed and how they interact with other systems in living cells. Unique capabilities include: Bio-SANS, a Small-Angle Neutron Scattering (SANS) facility for biological samples at the High-Flux Isotope Reactor (HFIR), Isotope Labeling Laboratories for cloning, gene expression, purification and characterization of labeled biological macromolecules, and Computational Techniques for the study of macromolecular complexes by SANS. Combined with selective Deuterium-labeling, it is possible to develop detailed structural models that enable the understanding of function. The focus of the CSMB is to bridge the information gap between cellular function and the molecular mechanisms that drive it.
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