National Human Genome Research Institute (NHGRI)

FLC Region

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Building 12A, Room 1033
12 South Drive, MSC 5612
Bethesda, MD 20892-5612
United States

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Laboratory Representative


Established in 1989, the National Human Genome Research Institute (NHGRI) led the National Institutes of Health's (NIH) contribution to the International Human Genome Project, which had as its primary goal the sequencing of the human genome. This project was successfully completed in April 2003. Now, the NHGRI's mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. To that end NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health.


A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The direction and vision for the future for NHGRI and for genomics research - A Vision for the Future of Genomics Research - was released in April 2003, coinciding with the 50th anniversary of James Watson and Francis Crick's seminal publication of the structure of DNA.

Technology Disciplines

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Mutations in the G Protein Coupled Receptor (GPCR) Gene Family in Melanoma
Mutations of the ERBB4 Gene in Melanoma
N-Acetyl Mannosamine as a Therapeutic Agent
New Targeted Therapy for Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia
Non-invasive Pan-Cancer Detection Method
Novel Codon-Optimized Gene Therapeutic for Methylmalonic Acidemia
Predicting Age of Onset of Niemann-Pick Disease
Rapid Integration Site Mapping
SAP/SH2D1A Knockout Mice: A Model for X-linked Lymphoproliferative Disease
Selections of Genes


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NIH Intramural Sequencing Center

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The National Human Genome Research Institute (NHGRI) solicits grant applications that relate to its scientific priorities and research interests. For some programs, the NHGRI participates with other Institutes and Centers (IC) at the National Institutes of Health (NIH). All NIH solicitations are published weekly as articles in the NIH Guide for Grants and Contracts[] and archived by date and announcement category. The archive can be browsed, or searched by keyword.

NHGRI welcomes innovative investigator-initiated applications and encourages investigators with novel ideas to discuss potential applications with program staff during the concept development stage of the application. Program staff members are very receptive to discussing your ideas and how they fit within the research mission of NHGRI.


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