Available Technology

BIOREACTOR DEVICE, AND METHOD AND SYSTEM FOR FABRICATING TISSUES IN THE BIOREACTOR DEVICE

A biological sampling platform includes a substrate and a first through hole disposed in the substrate to receive a first sample and to provide the first sample to a biological system in response to the biological sampling platform being disposed in the biological system, the substrate being cleavable to provide a discrete layer having a thickness effective for analysis of the discreet layer by transmission microscopy. A process for collecting a biological sample includes disposing a first through hole in a substrate; disposing a first sample in the first through hole to form a biological sampling platform; disposing the biological sampling platform in a biological system; providing the first sample to the biological system in response to the biological sampling platform being disposed in the biological system; and receiving a first biological sample from the biological system in the first through hole to collect the first biological sample. A bioreactor device, and method and system for fabricating tissues and growing cells and tissues in the bioreactor device, accommodates less than about 1 mL (or less than about 200 microliters) of local medium volume but sample sizes of about 100 microliters or greater. The bioreactor device includes a bioreactor chamber for containing a sample, where sample growth in response to mechanical, electrical, and biofactor stimulation is monitored through one or more optical ports. Embedded sensors are provided for measuring fluid pressure,pH, temperature, and oxygen tension. The bioreactor device can receive diefferent rypes of mechanical loadings, including fluid shear, hydrostatic pressure, matrix compression, and clinorotation. 
Inventors: 
Steven Hudson, Juan Manuel Taboas, Rocky Tuan
Patent Number: 
8,709,793
Internal Laboratory Ref #: 
05-017
Lab Representatives
Share to Facebook Share to Twitter Share to Google Plus Share to Linkedin