Available Technology

CHEMICAL MODIFICATION OF SUBSTRATES BY PHOTO-ABLATION UNDER DIFFERENT LOCAL ATMOSPHERES AND CHEMICAL ENVIRONMENTS

A laser was used to modify the charge on the surface(s) of a preformed polymeric microchannel (e.g. imprinted, embossed, injection molded, ablated, etc.). It is shown that the fluid flow induced by an electric field applied along the length of the channel increases in velocity in the regions that have been exposed to the laser, therefore indicating a change in the surface charge. Furthermore, the laser can be used to create well-defined spots within the channel that have a higher surface charge than the surrounding material. These spots have been shown to selectively bind proteins in a linear or 2-dimensional microarray pattern.
Inventors: 
Emanuel Waddell, Laurie Locacio, gary Kramer, Timothy Johnson
Patent Number: 
6,703,189
Internal Laboratory Ref #: 
01-008US
Lab Representatives
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