Available Technology

HGC-1, A Gene Encoding a Member of the Olfactomedin-Related Protein Family

The current technology embodies a newly identified gene, Human Granulocyte Colony-Stimulating Factor-Stimulated-Clone-1 (hGC-1) that has been cloned and characterized, and its protein sequence has been deduced. The gene is expressed in the bone marrow, prostate, small intestine, colon, and stomach, and has been mapped to chromosome 13 in a region that contains a tumor suppressor gene cluster. The gene is found to be selectively present in normal human myeloid lineage cells and is believed to play a role in allowing lymphocytes to differentiate properly. It is believed that the gene may play a role in human prostate cancer, multiple myeloma, B-cell chronic lymphocytic leukemia and other types of cancer and can be used diagnostically as well as in therapeutic screening activities.
Patent Abstract: 
The current technology embodies a newly identified gene, Human Granulocyte Colony-Stimulating Factor-Stimulated-Clone-1 (hGC-1) that has been cloned and characterized, and its protein sequence has been deduced. The gene is expressed in the bone marrow, prostate, small intestine, colon, and stomach, and has been mapped to chromosome 13 in a region that contains a tumor suppressor gene cluster. The gene is found to be selectively present in normal human myeloid lineage cells and is believed to play a role in allowing lymphocytes to differentiate properly. It is believed that the gene may play a role in human prostate cancer, multiple myeloma, B-cell chronic lymphocytic leukemia and other types of cancer and can be used diagnostically as well as in therapeutic screening activities. Griffin Rodgers (NIDDK)➽ more inventions... Jiachang Zhang ()➽ more inventions... WenLi Liu ()➽ more inventions... U.S. Pat:7,557,196issued 2009-07-07 PCT Application No. 10/497,890 Marguerite Miller, M.B.A. Email:millermarg@mail.nih.gov Phone: 301-496-9003 E-166-2001/0 Updated:Mar 1, 2005
Inventors: 

WenLi Liu ()

Jiachang Zhang ()

Internal Laboratory Ref #: 
E-166-2001/0
Lab Representatives
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