Available Technology

Lipid emulsions and uses thereof

One aspect of the present disclosure is a lipid emulsion composition comprising at least 20 percent (w/v) lipid, about 1 to about 5 percent (w/v) emulsifier, about 1 to about 5 percent (w/v) tonicity modifier, about 58 to about 88 percent (w/v) water, and optionally an inotrope and/or other compound such as vitamin K or CoQ10 that can act as an electron acceptor and thereby improve tissue redox state, or improve mitochondrial function and metabolism including oxidative phosphorylation, wherein the particles in the lipid emulsion have an average particle diameter of about 200 nm to less than 300 nm.

Another aspect of the present disclosure is a method of treating systemic drug toxicity in a subject in need thereof. The method comprises intravenously administering to the subject a lipid emulsion composition comprising at least 20 percent (w/v) lipid, about 1 to about 5 percent (w/v) emulsifier, about 1 to about 5 percent (w/v) tonicity modifier, about 58 to about 88 percent (w/v) water, and optionally an inotrope and/or other compound such as vitamin K or CoQ10 that can act as an electron acceptor and thereby improve tissue redox state, or improve mitochondrial function and metabolism including oxidative phosphorylation, wherein the particles in the lipid emulsion have an average particle diameter of about 200 nm to less than 300 nm.

applications 

PCT/US2019/033997

Reps: 
Inventors: 

Guy Weinberg

Christopher Bryant

Technology Type(s): 
lipid emulsions
Internal Laboratory Ref #: 
2020-147
Patent Status: 
pending
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