Available Technology

Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3)

The invention relates to monoclonal antibodies that bind to the transcription factor NCOA6 (ASC-2, AIB-3, TRB, TRAP250, NRC). The antibodies have proven successful reagents for Western blotting and for purifying complexes containing NCOA6. The Western blot experiments revealed that NCOA6 is over-expressed in several breast cancer cell lines, and the purification experiments identified a protein complex containing NCOA6 (the ASCOM complex). The monoclonal antibodies may be useful reagents for studying the role of NCOA6 in transcription and for studying the ASCOM complex.
Patent Abstract: 
The invention relates to monoclonal antibodies that bind to the transcription factor NCOA6 (ASC-2, AIB-3, TRB, TRAP250, NRC). The antibodies have proven successful reagents for Western blotting and for purifying complexes containing NCOA6. The Western blot experiments revealed that NCOA6 is over-expressed in several breast cancer cell lines, and the purification experiments identified a protein complex containing NCOA6 (the ASCOM complex). The monoclonal antibodies may be useful reagents for studying the role of NCOA6 in transcription and for studying the ASCOM complex. Paul Meltzer(NHGRI)➽ more inventions... Young-Hwa Goo et al., "Activating Signal Cointegrator 2 Belongs to a Novel Steady-State Complex That Contains a Subset of Trithorax Group Proteins," Mol. Cell. Biol. (Jan 2003) 23(1):140-149; DOI: 10.1128/MCB.23.1.140-149.2003. Soo-Kyung Lee et al., "A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptorsin Vivo," J. Biol. Chem. (26 Nov 1999) 274(48):34283-34893. Eggerton Campbell, Ph.D. Email:eggerton.campbell@nih.gov Phone: 301-402-1648 E-168-2005/0 Updated:Aug 1, 2005
Internal Laboratory Ref #: 
E-168-2005/0
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