Available Technology

Software System for Quantitative Assessment of Vasculature in Three Dimensional Images

This invention offered for licensing and further development is a software system that provides the capability of efficiently extracting, visualizing and quantifying three dimensional vascular networks from medical and basic research images. Deregulation of angiogenesis plays a major role in a number of human diseases, most notably cancer. A substantial increase in the research effort in this field over the past decade has deepened the understanding of the angiogenic process. However, the lack of methods and software to quantitatively assess vasculature in patients has considerably hampered the ability to directly study the angiogenesis process, as well as to discover and develop new therapeutics to modulate angiogenesis. The present invention provides new semi-automated computer algorithms, statistical methods and user friendly visualization tools for rapid and intuitive quantitative evaluation of vasculature in three dimensional data sets obtained through non-invasive imaging techniques such as MRI, CT-Scans, confocal microscopy, microCT, etc. The methods and software embodied in this invention provide a three dimensional quantitative capability in the clinic as a vascular diagnostic tool and in basic research projects to evaluate changes in vascular network systems.

Patent Abstract: 

This invention offered for licensing and further development is a software system that provides the capability of efficiently extracting, visualizing and quantifying three dimensional vascular networks from medical and basic research images. Deregulation of angiogenesis plays a major role in a number of human diseases, most notably cancer. A substantial increase in the research effort in this field over the past decade has deepened the understanding of the angiogenic process. However, the lack of methods and software to quantitatively assess vasculature in patients has considerably hampered the ability to directly study the angiogenesis process, as well as to discover and develop new therapeutics to modulate angiogenesis. The present invention provides new semi-automated computer algorithms, statistical methods and user friendly visualization tools for rapid and intuitive quantitative evaluation of vasculature in three dimensional data sets obtained through non-invasive imaging techniques such as MRI, CT-Scans, confocal microscopy, microCT, etc. The methods and software embodied in this invention provide a three dimensional quantitative capability in the clinic as a vascular diagnostic tool and in basic research projects to evaluate changes in vascular network systems.

Inventors: 

Christopher Kurcz

Lab Representatives
Share to Facebook Share to Twitter Share to Google Plus Share to Linkedin