NCI Technology Opportunities Webinar: Single Domain Antibodies Targeting SARS-CoV-2 for Treating COVID-19

Webinar
September 21, 2021

NCI Technology Opportunities Webinar: Single Domain Antibodies Targeting SARS-CoV-2 for Treating COVID-19

Join the National Cancer Institute (NCI) for a webinar discussing the opportunity to license or co-develop a potential therapeutic treatment for COVID-19. SARS-CoV-2 infects the host via its spike (S) protein, which contains a receptor binding domain (RBD) that binds to an angiotensin converting enzyme 2 (ACE2) receptor on human cells to facilitate viral entry and infection. NCI’s Dr. Mitchell Ho will speak on how his lab isolated three lead nanobodies, 7A3, 1B5, and 2F7, which have been found to be highly effective at blocking RBD-ACE2 binding interactions. This means that this nanobody panel has the potential to prevent the SARS-CoV-2 virus from binding to and entering host cells to cause a COVID-19 infection. Due to their small size and high stability, the nanobodies may be administered by an inhaler, making them ideal for respiratory infections such as COVID-19.

This is a great opportunity as there are very few therapeutics available that directly target the SARS-CoV-2 novel coronavirus. This technology has many commercial applications, including neutralizing nanobodies, nanobody-Fc fusion proteins as standard antibody therapy, antibody-drug conjugates (ADCs), immunotoxins, diagnostic reagents (in vivo virus imaging), and CARs (CAR T, NK, and macrophage). This technology is pre-clinical and patent pending.

Why attend?
* Assess co-developing and/or licensing this technology
* Interact with the inventor, ask questions and provide feedback
* Learn the advantages of partnering with the NCI