Available Technology

Novel Antigen for Use as Vaccine Against Nematode Infection

This invention describes a new vaccine againstStrongyoides stercoralis, which establishes a parasitic infection that affects an estimated 100-200 million people worldwide. The potential for fatal disease associated withS. stercoralisinfection and the difficulty in treating hyperinfection underscores the need for prophylactic vaccines against the disease. This vaccine usesS. stercoralisimmunoreactive antigen (SsIR); a novel antigen capable of providing 70-90 % protection for mice immunized with the antigen. In addition, sera from immunized mice have also been used to effectively protect naive mice from infection. The invention may also have potential use in diminishing allergic responses, asStrongyoides stercoralisinfection has been shown to reduce the murine response to allergens. Consequently, SsIR may be used to immunize individuals and reduce the allergic response. The antigen may also be used to identify homologous antigens from other parasitic nematodes that may be important for vaccine development.
Abstract: 
This invention describes a new vaccine againstStrongyoides stercoralis, which establishes a parasitic infection that affects an estimated 100-200 million people worldwide. The potential for fatal disease associated withS. stercoralisinfection and the difficulty in treating hyperinfection underscores the need for prophylactic vaccines against the disease. This vaccine usesS. stercoralisimmunoreactive antigen (SsIR); a novel antigen capable of providing 70-90 % protection for mice immunized with the antigen. In addition, sera from immunized mice have also been used to effectively protect naive mice from infection. The invention may also have potential use in diminishing allergic responses, asStrongyoides stercoralisinfection has been shown to reduce the murine response to allergens. Consequently, SsIR may be used to immunize individuals and reduce the allergic response. The antigen may also be used to identify homologous antigens from other parasitic nematodes that may be important for vaccine development.
applications: 
Inventors: 
Thomas Nutman
Patent Number: 
61/301,426 PCT Application No. PCT/US2011/023320
Internal Laboratory Ref #: 
E-084-2010/0
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