National Human Genome Research Institute (NHGRI)

FLC Region

Security Lab



Building 12A, Room 1033
12 South Drive, MSC 5612
Bethesda, MD 20892-5612
United States

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Laboratory Representative


Established in 1989, the National Human Genome Research Institute (NHGRI) led the National Institutes of Health's (NIH) contribution to the International Human Genome Project, which had as its primary goal the sequencing of the human genome. This project was successfully completed in April 2003. Now, the NHGRI's mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. To that end NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health.


A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The direction and vision for the future for NHGRI and for genomics research - A Vision for the Future of Genomics Research - was released in April 2003, coinciding with the 50th anniversary of James Watson and Francis Crick's seminal publication of the structure of DNA.

Technology Disciplines

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A Mouse Model of Multiple Endocrine Neoplasia, Type I
A Parameterized Model for Simulating Microarrays
AIB-1, A Steroid Receptor Co-Activator Amplified In Breast And Ovarian Cancer
Antagonists of the Hedgehog Pathway as Treatment of Heterotopic Ossification, Vascular Calcification, and Pathologic Mineralization
Blood-Based Assay for the Diagnosis and Monitoring of Hyposialylation Disorders
C57BL/6J Embryonic Stem Cell Lines Generated Using Serum-Free Media
Device and Method for Direct Measurement of Isotopes of Expired Gases: Application in Research of Metabolism and Metabolic Disorders, and in Medical Screening and Diagnostics
Diagnostic Markers for Melanoma
Encapsulated N-Acetylmannosamine or N-Acetylneuraminic Acid as a Therapeutic Agent for Increasing Sialylation in Certain Muscular Atrophies, Kidney Disorders, Cancers or Poor Immune Function
ERBB4 Mutations Identified in Human Melanoma Metastasis Cell Lines (2690, 2379, 2197, 2183, 2535, 2645, 1770, 2359, 2238, 2319, 2190)


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NIH Intramural Sequencing Center

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The National Human Genome Research Institute (NHGRI) solicits grant applications that relate to its scientific priorities and research interests. For some programs, the NHGRI participates with other Institutes and Centers (IC) at the National Institutes of Health (NIH). All NIH solicitations are published weekly as articles in the NIH Guide for Grants and Contracts[] and archived by date and announcement category. The archive can be browsed, or searched by keyword.

NHGRI welcomes innovative investigator-initiated applications and encourages investigators with novel ideas to discuss potential applications with program staff during the concept development stage of the application. Program staff members are very receptive to discussing your ideas and how they fit within the research mission of NHGRI.


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