National Human Genome Research Institute (NHGRI)

FLC Region

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Building 12A, Room 1033
12 South Drive, MSC 5612
Bethesda, MD 20892-5612
United States

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Established in 1989, the National Human Genome Research Institute (NHGRI) led the National Institutes of Health's (NIH) contribution to the International Human Genome Project, which had as its primary goal the sequencing of the human genome. This project was successfully completed in April 2003. Now, the NHGRI's mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. To that end NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health.


A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The direction and vision for the future for NHGRI and for genomics research - A Vision for the Future of Genomics Research - was released in April 2003, coinciding with the 50th anniversary of James Watson and Francis Crick's seminal publication of the structure of DNA.

Technology Disciplines

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Isocitrate Dehydrogenase 1 (IDH1) R132 Mutation Human Melanoma Metastasis Cell Line
LMNA Gene and Its Involvement in Hutchinson-Gilford Progeria Syndrome and Arteriosclerosis
MEN1, The Gene For Multiple Endocrine Neoplasia Type 1
Methods and Materials for Identifying Polymorphic Variants, Diagnosing Susceptibilities, and Treating Disease
Methods for Analyzing High Dimensional Data for Classifying, Diagnosing, Prognosticating, and/or Predicting Diseases and Other Biological States
Methods for Detecting Cancer Cells
Model Cell Lines With and Without AKT1 Mutations Derived from Proteus Syndrome Patients
Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3)
Mouse Model for Methylmalonic Acidemia, an Inherited Metabolic Disorder
Mutations in the G Protein Coupled Receptor (GPCR) Gene Family in Melanoma


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NIH Intramural Sequencing Center

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The National Human Genome Research Institute (NHGRI) solicits grant applications that relate to its scientific priorities and research interests. For some programs, the NHGRI participates with other Institutes and Centers (IC) at the National Institutes of Health (NIH). All NIH solicitations are published weekly as articles in the NIH Guide for Grants and Contracts[] and archived by date and announcement category. The archive can be browsed, or searched by keyword.

NHGRI welcomes innovative investigator-initiated applications and encourages investigators with novel ideas to discuss potential applications with program staff during the concept development stage of the application. Program staff members are very receptive to discussing your ideas and how they fit within the research mission of NHGRI.


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