COVID-19 News

NIAID awards Chrysalis $912K to help minimize vascular effects of COVID-19

Chrysalis BioTherapeutics, Inc., a clinical-stage biotechnology company developing regenerative drugs for acute organ injury caused by radiation exposure, announced today that the National Institute of Allergy and Infectious Disease (NIAID), part of the National Institutes of Health, awarded the Galveston, Texas-based company $912,157 to fund preclinical development of its investigational drug TP508 for SARS-CoV-2 infection. The contract award includes an option to conduct a Phase I human clinical trial to demonstrate safety prior to initiating efficacy trials in COVID-19 patients.

“This award will allow us to evaluate TP508 as a potential solution to prevent thrombosis and systemic vascular damage caused by SARS-CoV-2 infection,” said Chrysalis CEO, Dr. Darrell Carney.

TP508 has already been tested in multiple clinical trials for bone repair and healing of diabetic foot ulcers, with no drug-related adverse effects observed among ~600 participants. TP508 is also currently being developed with NIAID funding as a medical countermeasure for acute and delayed effects of radiation exposure. Preclinical data have demonstrated that TP508 significantly increases survival when injected 24 hours after radiation exposure by restoring vascular and progenitor cell function.

“TP508 protects endothelial cells lining blood vessels and stimulates replacement of damaged cells in a number of tissues,” explained Chrysalis EVP, Dr. Laurie Sower. “Since SARS-CoV-2 infection causes significant vascular damage, we anticipate that TP508 may help prevent disease progression.”

This research will lay the groundwork for future Phase 2 clinical trials in COVID-19 patients.

Read more: https://www.businesswire.com/news/home/20200610005789/en/Chrysalis-BioTh...