Available Technology

Dual Expression Vector for DNA Vaccines

Available for licensing from the NIH is an expression vector for improved DNA vaccines. Activation of co-stimulatory molecules (e.g. signaling molecules, cytokines, chemokines) and the timing of the activation are important for adaptive immune response. This technology describes a new vector that expresses an antigen and a co-stimulatory molecule, the latter after a delay to allow accumulation of the antigen. It is known that in some circumstances an optimal immune response is achieved by administration of a co-stimulatory molecule after antigen delivery. The subject technology improves upon the existing concept by providing a vector for accomplishing this optimization in a single step. Exemplary animal studies have shown that the delayed expression of some co-stimulatory molecules in important signaling pathways resulted in enhancement of the cellular and/or humoral immune responses using HIV Env as a representative antigen.
Abstract: 
Available for licensing from the NIH is an expression vector for improved DNA vaccines. Activation of co-stimulatory molecules (e.g. signaling molecules, cytokines, chemokines) and the timing of the activation are important for adaptive immune response. This technology describes a new vector that expresses an antigen and a co-stimulatory molecule, the latter after a delay to allow accumulation of the antigen. It is known that in some circumstances an optimal immune response is achieved by administration of a co-stimulatory molecule after antigen delivery. The subject technology improves upon the existing concept by providing a vector for accomplishing this optimization in a single step. Exemplary animal studies have shown that the delayed expression of some co-stimulatory molecules in important signaling pathways resulted in enhancement of the cellular and/or humoral immune responses using HIV Env as a representative antigen.
applications: 
Inventors: 
Gary Nabel
Patent Number: 
PCT/US2006/044522 US Application No. 60/737,896
Internal Laboratory Ref #: 
E-043-2006/0
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