National Center for Computational Toxicology (NCCT)

FLC Region

Security Lab



109 T.W. Alexander Drive
Research Triangle Park, NC 27709
United States

Want more information? Contact a representative below.

Laboratory Representative


The National Center for Computational Toxicology (NCCT) is the largest component of EPA's Computational Toxicology Research Program. It was established in 2005 to coordinate computational toxicology research on chemical screening and prioritization, informatics and systems modeling. NCCT is involved in the following areas:

  • Applies mathematical and advanced computer models to help assess chemical hazards and risks to human health and the environment.
  • Uses advances in informatics, high-throughput screening technologies and systems biology to develop robust and flexible computational tools that can screen the thousands of chemicals for potential toxicity.
  • Actively seeks partnershipswith other government entities, private industries, academia and non-governmental organizations that provide chemicals, screening data, software and various chemical screening platforms to advance this research.
  • Works closely with EPA's offices, regions and other research labs.
  • Has staff with a wide-range of expertise including systems biology, engineering, toxicology, physics, statistics, biology, computational chemistry, bioinformatics, management and public affairs.


The mission of the U.S. Environmental Protection Agency is to safeguard public health and the environment from harmful effects that may be caused by exposure to pollutants in the air, water, soil, and food. Protecting human health and the environment carries with it the challenge of assessing the risk that is posed by tens of thousands of chemicals. The large number of chemicals that the Agency must evaluate and the many different legal statutes that regulate chemicals have traditionally made it impossible for the Agency to evaluate every chemical with the most rigorous testing strategies. Instead, standard toxicity tests have been limited to only a small number of chemicals. Today, however, the young field of computational biology offers the possibility that, with advances in computational biology's subdisciplines (e.g., genomics, proteomics, and metabonomics), scientists may have the ability to develop a more detailed understanding of the risks posed by a much larger number of chemicals. The application of the tools of computational biology to assess the risk chemicals pose to human health and the environment is termed Computational Toxicology. Computational Toxicology is defined as the application of mathematical and computer models to predict adverse effects and to better understand the mechanism(s) through which a given chemical induces harm. Three strategic objectives of the computational toxicology initiative are to:

  • Improve understanding of the linkages in the continuum between the source of a chemical in the environment and adverse outcomes;
  • Provide predictive models for screening and testing; and
  • Improve quantitative risk assessment.

Technology Disciplines


No Technologies

Displaying 1 - 7 of 7
The National Center for Computational Toxicology
The National Center for Environmental Assessment
The National Center for Environmental Research
The National Exposure Research Laboratory
The National Health and Environmental Effects Research Laboratory
The National Homeland Security Research Center
The National Risk Management Research Laboratory

No Equipment


EPA’s National Center for Environmental Research (NCER) supports funding for high-quality research by the nation's leading scientists and engineers that will improve the scientific basis for decisions on national environmental issues. NCER supports leading edge extramural research in exposure, effects, risk assessment and risk management by managing funding competitions through the agency’s Science to Achieve Results (STAR), People, Prosperity and the Planet (P3), STAR and Greater Research Opportunities (GRO) Fellowships, and Small Business Innovative Research (SBIR) Programs. Research Funding Opportunities

EPA's Brownfields program provides grants and technical assistance to communities, states, tribes, and other stakeholders, giving them the resources they need to prevent, assess, safely clean up, and sustainably reuse brownfields. Cleaning up and reinvesting in these properties protects the environment, reduces blight, and takes development pressures off greenspaces and working lands. EPA's Land Revitalization program works with communities, states, non-profits and other stakeholders to develop and test sustainable approaches for the reuse of formerly contaminated properties.

Chemicals can be found in many of the products we use in our everyday lives. Some chemicals pose risks to humans and the environment.Under the Toxic Substances Control Act (TSCA) and the Pollution Prevention Act, EPA evaluates potential risks from new and existing chemicals and finds ways to prevent or reduce pollution before it gets into the environment. Use this site to get information on chemicals and their regulation under TSCA, on ways to prevent and reduce pollution,and on safer chemicals, products and practices.

Under the Environmental Education Grants Program, EPA seeks grant proposals from eligible applicants to support environmental education projects that promote environmental awareness and stewardship and help provide people with the skills to take responsible actions to protect the environment. This grant program provides financial support for projects that design, demonstrate, and/or disseminate environmental education practices, methods, or techniques. Since 1992, EPA has distributed between $2 and $3.5 million in grant funding per year, supporting more than 3,600 grants.

Environmental Justice Grants and Cooperative Agreements Programs
  • Regional
    • The Environmental Justice Showcase Communities Project provides EPA Regional office funding to bring together governmental and non-governmental organizations to pool their collective resources and expertise on the best ways to achieve real results in communities. The successes and lessons learned in these demonstration projects will be used to help guide the design and implementation of future Environmental Justice projects and will help EPA increase its ability to address local environmental challenges in more effective, efficient, and sustainable ways.
  • National
    • EPA's National Clean Diesel Funding Assistance Program issues competitive grants through EPA Regional Offices to fund implementation of diesel emission reduction technologies on school buses, vessels and equipment used in ports, construction and agriculture among others. Eligible entities include units of government including federally recognized tribes and nonprofit organizations whose principle purpose is promotion of transportation or air quality. Community groups can also partner with eligible applicants to apply for grants.

The Exchange Network Grant Program provides funding to states, territoriesand federally recognized Indian tribes to support the development of the Environmental Information Exchange Network (EIEN).The primary outcome expected from Exchange Network assistance agreements is improved access to, and exchange of, high-quality environmental data from public and private sector sources. Applications should demonstrate support for and results towardEIENprogram priorities.

Since FY2002, EPA has awarded approximately $200million in assistance agreements to build the Environmental Information Exchange Network. All 50 states, five territoriesand 87 federally recognized tribes have received grants to facilitate the development and implementation of the EIEN.

Each fiscal year, EPA expects to awardabout $10 millionto approximately40 to 50EIENprojects; awards for each projectcan beup to $500,000.The exact number of awarded grants will depend on:

  • the final amount of EPA's appropriation for the grant program,
  • the number of applications submitted to EPA by the application deadline,
  • the amounts of proposed budgets,and
  • the outcome of application reviews.

Every year, EPA awards over $4 billion in funding for grants and other assistance agreements. From small non-profit organizations to large state governments, EPA works to help many visionary organizations achieve their environmental goals. With countless success stories over the years, EPA grants remain a chief tool in the advancement of human health and the environment.


No Funds


No Publications


No Awards


No News


No Successes


No Licenses