Address
Bldg 31, Room 2A32, MSC 2425
31 Center Drive
Bethesda, MD 20892-2425
United StatesDescription
The National Institute of Child Health and
Human Development (NICHD) was initially established to investigate
the broad aspects of human development as a means of understanding
developmental disabilities, including mental retardation, and the
events that occur during pregnancy. Today, the Institute conducts
and supports research on all stages of human development, from
preconception to adulthood, to better understand the health of
children, adults, families, and communities.
Mission
The mission of the NICHD is to ensure that
every person is born healthy and wanted, that women suffer no
harmful effects from reproductive processes, and that all children
have the chance to achieve their full potential for healthy and
productive lives, free from disease or disability, and to ensure
the health, productivity, independence, and well-being of all
people through optimal rehabilitation. The NICHD has made
revolutionary progress toward achieving its goals. Since the
Institute was founded: infant death rates in the United States have
dropped more than 70 percent, with much of this decline resulting
from NICHD-sponsored research; survival rates for respiratory
distress syndrome have gone from 5 percent in the 1960s, to 95
percent today, due to advances in respirator technologies and the
availability of replacement lung surfactant, resulting from the
research efforts of the NICHD and other Institutes; the rate of
sudden infant death syndrome has dropped more than 50 percent,
since the NICHD-led Back to Sleep education campaign to reduce the
risk of SIDS began; transmission of HIV from infected mother to
fetus and infant has dropped from 25 percent to less than 2
percent, as a result of NICHD's efforts in collaboration with other
agencies and organizations; the incidence of Haemophilus Influenzae
B (Hib), once the leading cause of acquired mental retardation, has
dropped more than 99 percent, because of development of the Hib
vaccine by NICHD scientists, which has nearly eliminated this
disease; congenital hypothyroidism, once responsible for many cases
of mental retardation, no longer has an impact on cognitive
development because of screening techniques used to detect the
condition in all newborns in time to allow treatment to prevent its
effects; Phenylketonuria, a disorder that also caused mental
retardation in many individuals, has been successfully eliminated
as a factor in cognitive development through newborn screening and
dietary therapy; infertility that at one time kept couples from
having babies of their own often can be treated and reversed; sound
scientific information about the safety and effectiveness of
different contraceptive methods for women and men is now available;
many social, physical, and behavioral rehabilitation treatments for
people with mental, developmental, and physical disabilities are
now available.
Technology Disciplines
Displaying 1 - 5 of 5
NICHD Microscopy and Imaging Core (MIC)
Security Clearance : Non Security LabSquare Footage: 0
The NICHD Microscopy and Imaging Core (MIC) is designed as a multi-user research facility providing training and instrumentation for high resolution microscopy and image processing. The core is located on the ground floor of building 35A. It is equipped with several point scanning confocal microscopes (Zeiss LSM 510 meta inverted, Zeiss LSM 510 meta upright 2-photon, Zeiss 780LSM inverted, Nikon Spinning Disk/Storm/TIRF), a sub-resolution imaging platform (PALM instrument), and three wide-field fluorescence microscopes (Olympus BX61 upright, Olympus Wide Field Inverted,Olympus and Zeiss Lumar stereo-microscopes), together with a Jeol 1400 Transmission Electron Microscope. The mission of the Core is to provide training, support and instruments for all investigators in PNRC who require high-resolution microscopy in their research. In addition, the Core is involved in technology development focused on improving, automating, and providing enhanced access to advanced imaging technologies, including: Confocal Microscopy Time-lapse imaging Fluorescence methodologies (FRAP, FRET, uncaging, photo-activation) Sub-resolution microscopy (TIRF, PALM) Multi--photon imaging Image processing
Molecular Genomics Laboratory (MGL)
Address:
10 Center Dr, Rm 9D41
Bethesda
Region:
Security Clearance : Non Security LabSquare Footage: 0 Lab Reps:
Nichddirmolgenomicslab
The Molecular Genomics Laboratory (MGL) at the Eunice Kennedy Shriver National Institutes of Child Health and Human Development provides DNA and RNA sequencing services for genomic and genetic research. Our services include full gene analysis by DNA sequencing (whole exome, targeted exome and gene-specific sequencing), as well as whole transcriptome sequencing (RNA-Seq), microRNA sequencing, microbiome sequencing, bisulfite sequencing (DNA methylome), ChIP-Seq and ribosomal profiling. The MGL provides significant primary data processing and downstream bioinformatic support. We can assist in designing experiments or sequencing strategies (for example, optimization of targeted exome design). Our mission is to offer accurate and innovative tools to facilitate research into the diagnosis, counseling and treatment of hereditary disorders.
NICHD Biomedical Mass Spectrometry Core Facility
Security Clearance : Non Security LabSquare Footage: 0
The NICHD Biomedical Mass Spectrometry Core Facility was created under the auspices of the Office of the Scientific Director to provide high-end mass-spectrometric services to scientists within the NICHD Division of Intramural Research (DIR). Particular focus has been in the areas of proteomics, biomarker discovery, protein characterization, and detection of post-translational modifications. The Facility also performs quantitative analyses of small bio-molecules, including lipids and steroids. The Facility is located in the 9D corridor of Building 10 on the NIH campus.
NICHD Core Facilities (Various)
Address:
9609 Medical Center Drive, Room 1E-542, MSC 9702
Rockville, MD 20850
United StatesRegion:
P: 240-276-5497E: mcguinnc@mail.nih.govSecurity Clearance : Non Security Lab Requires research collaboration agreement or CRADA with NIH and NIH Intramural Researcher
NICHD Zebrafish Core
Security Clearance : Non Security LabSquare Footage: 0
The core's goal is to help researchers of any expertise perform zebrafish experiments aimed at illuminating basic biology and human disease mechanisms, thereby advancing the NIH and NICHD 's research missions. A typical research question might investigate the function or regulation of a zebrafish gene and/or its ortholog from humans or another species. We are also happy to offer consultation for any other zebrafish-related projects you may be considering. The core is equipped to assist with the following methodologies: Gene expression and regulation studies In situ hybridization to characterize developmental expression patterns of zebrafish genes Zebrafish nucleic acid collection for downstream genomic and molecular applications Gain of gene function studies In vitro RNA synthesis RNA and DNA microinjection Transgenic animal production* Loss of gene function studies Design and microinjection of antisense morpholino oligonucleotides for transient loss of function Design, synthesis and microinjection of TALE nucleasesor CRISPR-Cas9 reagents to generate germ-line genetic mutants* Other methodologies Cryopreservation of transgenic and mutant zebrafish lines Importation of existing zebrafish lines Characterization of phenotypes by time-lapse photography
Funding Instruments
- Grant: Financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. A grant is used whenever an NIH Institute or Center (IC) anticipates no substantial programmatic involvement with the recipient during performance of the financially assisted activities.
- Contract: An award instrument used to acquire by purchase, lease, or barter, property or services from a non-federal party for the direct benefit or use of the federal government. For a contract, the government establishes detailed requirements to meet its perceived needs and decides on the entity to meet those needs.
- Cooperative Agreement: A financial assistance instrument under which substantial involvement is anticipated between the federal agency and the recipient during performance of the contemplated project or activity. These agreements are similar to grants, but federal staff have substantial scientific or programmatic involvement.
Lab Representatives
