National Institute of Diabetes and Digestive and Kidney Diseases

FLC Region

Security Lab



Building 12A, Room 3011
12 South Drive (MSC 5362)
Bethesda, MD 20892-5632
United States

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Laboratory Representative




The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) supports a wide range of medical research through grants to universities and other medical research institutions across the country. The Institute also supports government scientists who conduct basic, translational and clinical research across a broad spectrum of research topics and serious, chronic diseases and conditions related to the institute's mission. In addition, the NIDDK supports research training for students and scientists at various stages of their careers and a range of education and outreach programs to bring science-based information to patients and their families, health care professionals and the public.


The National Institute of Diabetes and Digestive and Kidney Diseases conducts and supports research on many of the most serious diseases affecting public health. The Institute supports much of the clinical research on the diseases of internal medicine and related subspecialty fields as well as many basic science disciplines. The Institute's Division of Intramural Research encompasses the broad spectrum of metabolic diseases such as diabetes, inborn errors of metabolism, endocrine disorders, mineral metabolism, digestive diseases, nutrition, urology and renal disease, and hematology. Basic research studies include biochemistry, nutrition, pathology, histochemistry, chemistry, physical, chemical, and molecular biology, pharmacology, and toxicology. NIDDK extramural research is organized into divisions of program areas:

  • The Division of Diabetes, Endocrinology, and Metabolic Diseases;
  • The Division of Digestive Diseases and Nutrition; and
  • The Division of Kidney, Urologic, and Hematologic Diseases.

The Division of Extramural Activities provides administrative support and overall coordination. A fifth division, the Division of Nutrition Research Coordination, coordinates government nutrition research efforts.

The Institute supports basic and clinical research through investigator-initiated grants, program project and center grants, and career development and training awards. The Institute also supports research and development projects and large-scale clinical trials through contracts.

Technology Disciplines

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Stat1LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies
The Whey Acidic Protein (WAP) Promoter and Its Use to Express Therapeutic Proteins in the Milk of Transgenic Mammals
Transgenic Mice Expressing CNO-sensitive Gq- or Gs-coupled Designer Receptors Selectively in Pancreatic Beta Cells
Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors
Transgenic Mice with Constitutively Active M3 Muscarinic Receptor in Islet Beta Cells
Triazole Derivatives of 4,7-disubstituted 2 naphthoic acid (PPTN) as P2Y14 Receptor Antagonists
Truncated Methanocarba Adenosine Derivatives as A3 Adenosine Receptor Antagonists
Use of Modified Peptide Nucleic Acids for Visualizing DNA
UTX LoxP Mouse Model for Oncology Research
Vitamin D Receptor Antagonists for Treating Breast Cancer


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Laboratory of Biochemistry and Genetics
Laboratory of Biological Modeling
Laboratory of Bioorganic Chemistry
Laboratory of Cell and Molecular Biology
Laboratory of Cellular and Developmental Biology
Laboratory of Chemical Physics
Laboratory of Endocrinology and Receptor Biology
Laboratory of Genetics and Physiology
Laboratory of Molecular Biology

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