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Laboratory Representative
Description
The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH's intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement and analysis. BEPS is centrally located on the main NIH campus, and provides expertise that spans technologies ranging in scale from near-atomic resolution to intact organisms.
Please click on the links below to learn more about BEPS's six Units:
The
Electron Microscopy Unit provides instrumentation, training, and
services for: immuno electron microscopy, electron tomography, and
specimen preparation, including cryo-techniques.
The
Infrared Imaging and Thermometry Unit provides expertise,
instrumentation, and training for: intraoperative and bedside
optical imaging of tissue (perfusion, oxygenation, and
temperature), passive microwave thermometry, multi-spectral imaging
without contrast agents, and remote sensing for clinical research
using cellphone technology.
The Micro
Analytical Immunochemistry Unit specializes in micro-immunoaffinity
capillary electrophoresis, multianalyte QuansysTM ELISA arrays,
custom immunoassays for microliter and sub-microliter samples, and
characterization of biological molecule interactions using surface
plasmon resonance (SPR).
The
Microfabrication and Microfluidics Unit specializes in: rapid
design and fabrication of microfluidic devices from single or
multilayer templates, microfabrication in silicon/glass, PDMS,
thermoplastics, and agarose, structured surface modification,
including micro contact printing, and plasma treatment of PDMS
devices for irreversible bonding or for surface activation.
The
Quantitative Methods for Macromolecular Interactions (QMMI) Unit
specializes in the following: biophysical characterization of
individual macromolecules and their interactions, measurement of
solution-phase molecular weight, sedimentation coefficients, and
translational diffusion coefficients, hydrodynamic radii, and
overall asymmetry of macromolecules or their assemblies,
establishment of the stoichiometry of complexes, and insight into
secondary structure or changes in structure upon ligand
binding.
The
Scanning Probe Microscopy Unit specializes in nanoscale imaging of
molecular complexes, lipid bilayers, cells and tissues, molecular
recognition, protein unfolding, force spectroscopy, high resolution
viscoelastic property mapping, correlated AFM and fluorescence
microscopy, and mathematical modeling, image analysis, finite
element analysis.