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Ketone Bodies to Protect Tissues From Damage by Ionizing Radiation

Laboratory: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Technology: The invention relates to methods of using ketogenic compounds to protect against the adverse effects of radiation exposure, including ionizing radiation tissue damage. National Institutes of Health (NIH) inventors have discovered that ketone esters can be used to reduce tissue damage if they are administered before or after exposure to radiation. Specifically, the invention relates to esters and oligomers of (R)-3-hydroxybutyrate that are capable of elevating blood levels of (R)-3-hydroxybutyrate and acetoacetate to sufficient levels to reduce cell death caused by radiation-induced damage to DNA and RNA. The development of effective radioprotectant molecules such as these is of great importance in reducing tissue damage following intentional or accidental radiation exposure. This discovery can also increase the therapeutic efficacy of radiation therapies by protecting non-target tissues from incidental radiation damage. Applications:
  • Effective therapeutic agent for reducing tissue damage following radiation exposure
  • Protects populations subjected to accidental, incidental, or military exposure to radiation
  • Protects non-target tissue during radiation therapy
  • Can be administered before or after radiation damage
  • Stable at room temperature, allowing easy storage
Opportunity: A patent application has been filed, and licensing opportunities are available. The NIAAA is also seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Ketone Bodies to Protect Tissues from Damage by Ionizing Radiation. In vitro data is available. Contact: For collaboration opportunities, please contact Peter B. Silverman, Ph.D., J.D. For licensing information, please contact Charlene Sydnor, Ph.D. View the full listing here.
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