Ready for Transfer

Rapid Polymer Sequencer

RFT image

The Rapid Polymer Sequencer, a device that sequences DNA at a rate of a million bases per second, is available for licensing from NASA Ames Research Center.

Solid-state nanopore-based analysis of nucleic acid polymers is revolutionary. No other technique can determine information content in single molecules of genetic material at such rapid speeds. Since individual molecules are counted, the output is intrinsically quantitative. The nanopore approach is more generalized than any other method and may be used to analyze any polymer molecule, applying nanofabrication, nanoelectronic components, and high-speed signal acquisition.

NASA’s solid-state nanopore sensor will permit sequencing DNA at a much faster rate. It uses high-speed electronic equipment with exceptional signal acquisition capabilities to analyze the electronic properties of individual subunits of DNA or RNA to obtain a linear composition of each genetic polymer molecule. The nanopore sensor’s unmatched speed and sensitivity of DNA detection and sequencing will enable personalized molecular medicine, revolutionary modification of the agriculture and food industry, and decoding of ecosystem-wide genetic variation.

This sensor can bring the complete DNA sequence information underlying the biodiversity of our planet within reach. It is so robust that not only can it enable a complete understanding of the molecular basis of life here on Earth, it could also help us detect life on other planets.

Benefits

  • Permits fine control over pore dimensions
  • Does not alter the chemical composition of substrate
  • Increased speed, sensitivity, and simplicity of operation
  • Reproducible
  • Entire pipette is composed of pure material (quartz glass)

Applications

  • Medical and scientific
  • Real-time, molecular astronaut health monitoring
  • Devices based on nanopore’s pipettes
  • Pathogen and environment monitoring systems
  • DNA or RNA detection and sequencing
  • Agriculture and food industry
  • Space research

To inquire about this opportunity, contact Ames Research Center’s Technology Transfer Office and cite Reference Number TOP2-157.