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NCI t cells for FLC e1413989542609

Focused ion beam scanning electron microscopy imaging reveals the complex connections between uninfected (purple/blue) and HIV-infected (yellow/green) human T cells. This state-of-the-art technique, used by scientists in the National Cancer Institute’s (NCI) Laboratory of Cell Biology, in partnership with the National Library of Medicine (NLM), can directly image both tiny virions and whole cells in 3D, catching HIV in the act.

NCI’s Laboratory of Cell Biology Biophysics Section works to understand cells and viruses at molecular resolution. Led by Dr. Sriram Subramaniam, this group combines novel 3D imaging techniques with computational and cell biological tools to study protein complexes relevant to signal transduction, HIV/AIDS, and cancer.

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