Obsessive Compulsive Disorder

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PTH2 and PTH1 Receptor Ligands

Parathyroid hormone receptors found on osteoblasts in bone and renal tubule cells in kidney elevate blood calcium levels when stimulated by parathyroid hormone (PTH) and PTH-related protein (PTHrP). Excessive secretion of PTH from the parathyroid gland results in primary hyperparathyroidism...
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Rat Model for Alzheimer's Disease

The present invention is directed to a transgenic rat model of Alzheimer's Disease (AD) termed TgF344-19+/-. The invention rat overexpresses two human genes (APPswe and PS1?E9 genes), each of which are believed to be independent dominant causes of early-onset AD. The hemizygote exhibits major...
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Serotonin-Deficient Knock-out Mouse

Serotonin is an important modulator of many developmental, behavioral, and physiological processes, and it has been implicated in depression, anxiety, schizophrenia, obsessive compulsive disorders, and substance abuse. Serotonin’s pharmacology is extremely complex and it is mediated by seven of...