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5-Substituted Derivatives of Conformationally Locked Nucleoside Analogues

Phone: 301-624-8775
Patent Abstract: 
This invention relates to 5-substituted derivatives of conformationally locked nucleoside analogues and methods of using these derivatives as antiviral and anticancer agents. The compounds contemplated by the invention are nucleoside analogues where the 5-substituent is a halogen, alkyl, alkene, halovinyl or alkyne group, and the nucleotide base is cytosine or uracil. The analogues are particularly effective in treating viral infections, specifically infections of DNA viruses such as Herpes simplex virus (HSV), Varicella zoster virus (VSV), Epstein Barr virus (EBV), and Cytomegalovirus (CMV) as well as members of the Poxviridae family. The inventors have demonstrated in plaque reduction assays that 5-substituted uracils (bromo, iodo, and bromovinyl) attached to a bicyclo[3.1.0]hexane template are thirty times more potent than acyclovir against HSV-1 and HSV-2. Victor Marquez(NCI)➽ more inventions... Pamela Russ (NCI)➽ more inventions... U.S. Pat:7,009,050issued 2006-03-07 PCT Application No. PCT/US01/23246 Lauren Nguyen-Antczak, Ph.D., J.D. Email:lauren.nguyen-antczak@nih.gov Phone: 301-624-8752 E-249-2000/0 Updated:Jun 1, 2001
Pamela Russ
Internal Laboratory Ref #: 
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