Available Technology

Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnostics

This CDC developed invention pertains toStreptococcus pneumoniaeprotein "pneumococcal fimbrial protein A (PfpA)," as well as the encodingpfpAgene.S. pneumoniaelinked pneumococcal disease is prevalent among the very young, the elderly and also immunocompromised individuals. This invention covers the breadth of directly PfpA-related technology that might be employed for development of diagnostic tests forS. pneumoniaeand/or vaccines directed against the pathogen. In addition to the the intellectual property protected amino acid sequence and encoding plasmid, monoclonal antibodies and corresponding hybridomas are also available.
Benefits 
Easily adapted to a high-throughput assay for mass screening purposes -Can be formatted as an on-site, lateral-flow diagnostic; both PfpA antigen and anti-PfpA mAb are available
applications 
Inventors: 
Harold Russell
Internal Laboratory Ref #: 
E-157-1991/0
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