Available Technology

BSA 15-22: Bioprogrammable Crystallization of Multicomponent Functional Nanoparticle Systems

This invention describes a strategy for the creation of heterogeneous nanoparticle superlattices using DNA and carboxylic-based conjugation. In this approach, nanoparticles coated with DNA molecules can be programmed to self-assemble into three-dimensional superlattices. Such superlattices can be made from nanoparticles with different functionalities and could potentially exploit the synergetic properties of the nanoscale components.
Patent Abstract: 
Assembly in organized structures of DNA functionalized objects has mainly been limited to gold nanoparticles, largely because gold nanoparicles can be easily coated with a dense DNA shell by simply replacing the weak surfactants (e.g., citrate, CTAB etc.), used during the synthesis process, by thiolated DNA. For synthesis of nanoparticles with different compositions or with more complex morphologies, the functionalization is very difficult because surfactants that are routinely used with these nanoparticles bind tightly to the surface, making further functionalization very difficult. Here a general procedure is described for generating many types of nanoparticles, functionalizing them with DNA, and forming the functionalized nanoparticles into complex structures with long range three dimensional order.
This general method allows for the formation of multi-component functional nanoparticle systems from functionally diverse components. From a material perspective a wide variety of species and shapes can be formed wherein the functionalized nanoparticle includes a magnetic material, a plasmonic material, a photonic material, a catalytic material, or a biological material, and has a shape of an octahedron, a cube or a dodecahedron.
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