Available Technology

Calibrating Flow Mediated Dilation Measurements to Prevent and Identify Treatments for Cardiovascular Disease 2015-056

Berkeley Lab’s Jonathan Maltz, inventor of a cuff device to measure endothelial function, has developed a means of calibrating that device’s measurements with ultrasound-based flow mediated dilation (uFMD) measurements. This technology enables health care professionals and researchers to 1) take advantage of existing research on the affect of cardiovascular health factors (diet, physical activity, medical interventions, etc.), typically assessed using uFMD, and 2) correct for uMFD’s underestimation of smooth muscle response in patients with stiffer arteries, potentially improving results of medical interventions. Both endothelial function and endothelium-independent vasodilation may be studied using this approach. Berkeley Lab’s existing cuff-based flow mediated dilation (cFMD) technology, differs from uFMD by measuring blood vessel cross-sectional area changes rather arterial diameter changes. In addition to integrating well with the existing cFMD device, the new calibration technology can work with other dilation measurement systems.
Benefits: 
: - Relates more accurate cuff-based flow mediated dilation (cFMD) measurements with the ultrasound-based flow mediated dilation (uFMD) measurements used in most research studies - Enables more accurate assessments of patients with stiffer arteries
applications: 
Internal Laboratory Ref #: 
2015-056
Patent Status: 
Patent pending. - Licensed in the field of human medical diagnostics and vascular health monitoring.
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