Available Technology

Cell Characterization by Phenotypic Analysis of Ligand Redistribution IB-2640

Jay Groves, Joe Gray and their colleagues at Berkeley Lab have developed a phenotypic cell marker that can identify metastatic cells. The researchers created an assay in which a live cell, with an intact membrane that contains receptors, is placed on top of a synthetic membrane that is deposited on a glass slide and contains ligands (see figure).
Benefits: 
Can be applied to living cells from biopsies - Compatible with samples as small as a single cell - May be scaled up to test multiple drugs simultaneously - Analyzes phenotype rather than gene or protein expression - Mimics and assesses receptor-ligand behavior at cell-cell contacts
applications: 
Internal Laboratory Ref #: 
IB-2640
Patent Status: 
Patent pending. Available for licensing or collaborative research.
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