Available Technology

Flowmeter for pressure-driven chromatography systems

A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 mum, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of muL/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.
Inventors: 

Phillip H. Paul

Don W. Arnold

Patent Number: 
US6532802
Patent Issue Date: 
April 18, 2003
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