Available Technology

HART mice

Androgen receptor (AR) plays a critical role in prostate cancer. Length of AR’s N-terminal glutamine (Q) tract has been associated with disease risk, and AR somatic mutation may influence disease progression. To study the basis for these effects in an animal model, the mouse AR gene was converted to the human sequence, using homologous recombination in embryonic stem cells.


HART mice allow study of human androgen receptor-related diseases in a mouse model

Technology Type(s): 
Recombinant mouse
Patent Status: 
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