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Novel Acylthiol Compositions and Methods of Making and Using Them Against HIV

Srivastava P, et al.
This invention provides a novel family of acylthiols and uses thereof. More specifically, this invention provides effective inhibitors of HIV that selectively target its highly conserved nucleocapsid protein (NCp7) by interacting with metal chelating structures of a zinc finger-containing protein. Because of the mutationally intolerant nature of NCp7, drug resistance is much less likely to occur with compounds attacking this target. In addition, these drugs should inactivate all types and strains of HIV and could also inactivate other retroviruses, since most retroviruses share one or two highly conserved zinc fingers that have the CCHC motif of the HIV Ncp7. Finally, this invention could be very useful for the large-scale practical synthesis of HIV inhibitors, because these compounds can be prepared by using inexpensive starting materials and facile reactions. Thus, it opens the possibility that an effective drug treatment for HIV could be made available to much larger populations. These thioesters may also be used as an active component in topical applications that serve as a barrier to HIV infection. John Inman(NIAID)➽ more inventions... Atul Goel (NCI)➽ more inventions... James Turpin (NCI)➽ more inventions... Ettore Appella (NCI)➽ more inventions... Marco Schito (NCI)➽ more inventions... U.S. Pat:7,528,274issued 2009-05-05 U.S. Pat:8,076,372issued 2011-12-13 US Application No. 60/310,133 US Application No. 12/414,321 Schito ML, et al.PMID 12639244 Srivastava P, et al.PMID 15556761 Jenkins LM, et al.PMID 15828823 Basrur V, et al.PMID 10809733 Turpin JA, et al.PMID 9888834 Marguerite Miller, M.B.A. Email:[email protected] Phone: 301-496-9003 E-329-2000/0 Updated:Mar 13, 2015

Marco Schito (NCI)

Ettore Appella (NCI)

James Turpin (NCI)

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