Viable Viruses with Foreign Tags
An attenuated porcine respiratory and reproductive syndrome virus vaccine has been engineered to harbor either one of two deletions and/or one of three small immunogenic tags at the two deletion sites. The eight viruses efficiently replicate, maintain the parental virus phenotype, and are stable in cell cultures.
Benefits
• The viruses are stable in cultured cells
• Allow efficient localization of nonstructural protein 2 (nsp2)
• Can be used to locate differently tagged nsp2 in co-infection studies
Applications
• Serves as a platform in developing new DIVA vaccines
• Molecular tool to study the role of nonstructural protein 2 in pathogenesis
Internal Laboratory Ref #:
133.16Lab Representatives
